Cell-Tissue Targeting & Imaging
Cell-Targeting Aptamer Ligands
The Problem
Drug candidates that prove positive in "test tube" (or in vitro) assays may face substantial problems when tested in animals, a necessary prerequisite before human clinical trials. These problems include absorption, distribution, metabolism, excretion, and toxicity.
The Solution
Aptagen's technique, involving molecules called aptamers, overcomes the limitation of the traditional pharmaceutical drug discovery process. The unique chemistry of modified aptamers permits the selection of drug candidates in whole animal models, bypassing the "test tubes" entirely, and taking drug development one step closer to human clinical trials. By using an animal model with the disease state of interest, specific knowledge of the pathology or disease condition is not needed. An added benefit is the significant reduction in the number of animals needed for drug evaluation before entering into human clinical trials.
Targeting a Difficult Cell or Tissue?
Let Aptagen develop a cell-targeting aptamer ligand.
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