Aptamer Discovery Kits
Discover what aptamers can do for you!
An aptamer is a small, single-stranded nucleic acid molecule (RNA or DNA, modified or unmodified) that can bind a target with high specificity and affinity. Aptamers typically interact with their targets via secondary and/or tertiary structure, such as stem/loop bulges and G-quartets. The formation of these structures depends on the primary nucleotide sequence of the aptamer.
Unlike antibodies, most aptamers are raised in vitro by a PCR-based, iterative process known as SELEX — Systematic Evolution of Ligands by Exponential Enrichment. SELEX isolates favorable target-binding sequences from extremely diverse, randomized pools of aptamers.
This kit demonstrates the use of Melting-Off SELEX, a selection strategy designed to produce structure-switching aptamers through a known and consistent mechanism.
