Z23 Anti-Vesicular Stomatitis Virus Aptamer Details
ID# 7958
Structure
Chemistry
DNA
Target
Vesicular Stomatitis Virus
Category
Other
Affinity (Kd)
EC50 =/< 80 nM
Length
39
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-dGpdGpdGpdApdCpdCpdTpdApdTpdCpdApdGpdGpdCpdGpdApdTpdGpdTpdGpdApdApdApdApdCpdTpdCpdTpdTpdApdTpdApdCpdCpdApdCpdTpdGpdGp-3'
Molecular Weight: 12015.87
Extinction Coefficient: 380500
Binding Conditions / Buffer
90% High Glucose DMEM, 10% Fetal Bovine Serum. Tested in vivo.
Binding Temp: 37°C
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Muharemagic D, Zamay A, Ghobadloo SM, Evgin L, Savitskaya A, et al. (2014) Aptamer-Facilitated Protection of Oncolytic Virus from Neutralizing Antibodies. Molecular Therapy--Nucleic Acids 3, e167. doi: 10.1038/mtna.2014.19
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