YPEN-1 Endothelial Cells (III.1) Aptamer Details

ID# 7605

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Structure

Chemistry

DNA

Target

YPEN-1 Endothelial Cells

Sequence (3-char table code)

G A C U/T

5'-dApdTpdApdCpdCpdApdGpdCpdTpdTpdApdTpdTpdCpdApdApdTpdTpdApdGpdGpdCpdGpdGpdTpdGpdCpdApdTpdTpdGpdTpdGpdGpdTpdTpdGpdGpdTpdApdGpdTpdApdTpdApdCpdApdTpdGpdApdGpdGpdTpdTpdTpdGpdGpdTpdTpdGpdApdGpdApdCpdTpdApdGpdTpdCpdGpdCpdApdApdGpdApdTpdApdTpdApdGpdApdTpdApdGpdTpdApdApdGpdTpdGpdCpdApdApdTpdCpdTp-3'

Molecular Weight: 29854.53

Extinction Coefficient: 961400

Binding Conditions / Buffer

Selection buffer: 50 mM Tris-HCl (pH 7.4), 5 mM KCl, 100 mM NaCl, 1 mM MgCl2, and 0.1% NaN3 with 1 ug/uL yeast tRNA.

Binding Temp: RT°C

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Blank et al. "Systematic Evolution of a DNA Aptamer Binding to Rat Brain Tumor Microvessels." The Journal of Biological Chemistry, >b>276(2001): 16464-16468.

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