XQ-P3 Aptamer Details
ID# 8137
Structure
Chemistry
DNA
Target
PD-L1
Category
Protein
Affinity (Kd)
15.36 nM
Length
63
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-dApdCpdCpdGpdApdCpdCpdGpdTpdGpdCpdTpdGpdGpdApdCpdTpdCpdApdTpdCpdTpdCpdGpdCpdTpdTpdTpdTpdTpdTpdCpdApdCpdGpdGpdTpdCpdCpdApdCpdApdCpdTpdApdCpdTpdApdTpdGpdApdGpdCpdGpdApdGpdCpdCpdTpdGpdGpdCpdGp-3'
Molecular Weight: 19261.5
Extinction Coefficient: 573400
Binding Conditions / Buffer
D-PBS supplemented with 4.5 g/L of glucose, 5 mM of MgCl2, 0.1 mg/mL of yeast tRNA, and 1 mg/mL of BSA
Binding Temp: 22°C
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Wu X, Li F, Li Y, Yu Y, Liang C, Zhang B, Zhao C, Lu A, Zhang G. A PD-L1 Aptamer Selected by Loss-Gain Cell-SELEX Conjugated with Paclitaxel for Treating Triple-Negative Breast Cancer. Med Sci Monit. 2020 Jun 23;26:e925583. doi: 10.12659/MSM.925583. PMID: 32574155; PMCID: PMC7331476.
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