XMU3 Aptamer Details
ID# 8092
Structure
Chemistry
DNA
Target
epithelial cell adhesion molecule (EpCAM)
Category
Cells
Affinity (Kd)
9.3 ± 1.3 nM
Length
92
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5’-dTpdCpdCpdApdGpdCpdApdCpdTpdCpdCpdApdCpdGpdCpdApdTpdApdApdCpdCpdCpdCpdGpdTpdCpdCpdTpdCpdGpdGpdApdApdApdGpdApdGpdCpdGpdCpdGpdGpdGpdCpdCpdTpdGpdGpdGpdApdCpdGpdGpdCpdTpdApdCpdTpdGpdCpdCpdCpdGpdGpdApdTpdTpdTpdApdTpdGpdTpdGpdTpdTpdApdTpdGpdCpdGpdTpdGpdCpdGpdApdCpdGpdGpdTpdGpdApdAp-3’
Molecular Weight: 28366.3
Extinction Coefficient: 860500
Binding Conditions / Buffer
PBS containing 0.55 mM MgCl2 and 0.2 mg/mL yeast tRNA, pH = 7.4
Binding Temp: 25°C
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Huang, M., Li, T., Xu, Y., Wei, X., Song, J., Lin, B., … Yang, C. J. (2020). Activation of Aptamers with Gain‐of‐Function by Small‐Molecule‐Clipping of Intramolecular Motifs. Angewandte Chemie International Edition. doi:10.1002/anie.202013570
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