XA-B217 Aptamer Details
ID# 8095
Structure
Chemistry
DNA
Target
Thy-1 membrane glycoprotein
Category
Protein
Affinity (Kd)
2 nM
Length
42
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5’-dTpdTpdGpdCpdCpdCpdApdCpdCpdGpdTpdApdCpdTpdGpdTpdGpdCpdApdGpdGpdTpdCpdGpdApdApdCpdTpdApdCpdApdGpdGpdCpdApdCpdGpdTpdCpdGpdTpdGp -3’
Molecular Weight: 12868.8
Extinction Coefficient: 389250
Binding Conditions / Buffer
10 mL of 20 mM Tris buffer (150 mM NaCl, pH 8.0)
Binding Temp: 22°C
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Wang H, Li X, Lai LA, Brentnall TA, Dawson DW, Kelly KA, Chen R, Pan S. X-aptamers targeting Thy-1 membrane glycoprotein in pancreatic ductal adenocarcinoma. Biochimie. 2021 Feb;181:25-33. doi: 10.1016/j.biochi.2020.11.018. Epub 2020 Nov 23. PMID: 33242496; PMCID: PMC7863625.
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