upanap-12 Aptamer Details
ID# 7837
Structure
Chemistry
2'-F-RNA
Target
Urokinase-type plasminogen activator
Category
Protein
Affinity (Kd)
N/A nM
Length
79
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-rGprGprGprGpfCpfCprApfCpfCprAprApfCprGprApfCprApfUpfUpfUprGpfCprGprApfCpfUprGpfUpfUprApfUprAprApfCpfCpfUprAprApfCprAprGpfCprGprApfCprGpfUprAprAprAprGprApfUprAprGpfUpfUprGprApfUprApfUprAprAprApfUprAprGpfUprGpfCpfCpfCprApfUprGprGprApfUpfCp-3'
Molecular Weight: 25480.22
Extinction Coefficient: 805500
Binding Conditions / Buffer
HBS, 2 mM MgCl2, 0.1% BSA, and 0.025% Tween20
Binding Temp: 37°C
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Daniel Miotto Dupont, Jeppe Buur Madsen, Roland Karl Hartmann, et al. Serum-stable RNA aptamers to urokinase-type plasminogen activator blocking receptor binding. RNA 2010 16: 2360-2369
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