U2 Aptamer Details
ID# 7882
Structure
Chemistry
DNA
Target
U87-EGFRvIII
Category
Cells
Affinity (Kd)
3.37 nM
Length
76
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
dApdTpdCpdCpdApdGpdApdGpdTpdGpdApdCpdGpdCpdApdGpdCpdApdTpdTpdTpdTpdGpdApdCpdGpdCpdTpdTpdTpdApdTpdCpdCpdTpdTpdTpdTpdCpdTpdTpdApdTpdGpdGpdCpdGpdGpdGpdApdTpdApdGpdTpdTpdTpdCpdGpdTpdGpdGpdApdCpdApdCpdGpdGpdTpdGpdGpdCpdTpdTpdApdGpdTp
Molecular Weight: 23483.29
Extinction Coefficient: 717000
Binding Conditions / Buffer
0.45 g of glucose, 10 mg yeast tRNA, 5 mg salmon sperm DNA, 0.1 g BSA and 0.5 ml of 1 M MgCl2 in 100 ml of 1X phosphate-buffered saline [PBS]
Binding Temp: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Wu, X. et al. "Cell-SELEX Aptamer for Highly Specific Radionuclide Molecular Imaging of Glioblastoma In Vivo." PLOS One 2014, 9:3.
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