Trypanosoma cruzi-Fibronectin Parasite Receptor (F4) Aptamer Details

ID# 7567

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Structure

Chemistry

2'-F-RNA

Target

Trypanosoma cruzi-Fibronectin Parasite Receptor

Sequence (3-char table code)

G A C U/T

5'-rApfCpfCprGprAprGpfUpfCpfCprAprGprAprAprGpfCpfUpfUprGpfUprAprGpfUprApfCpfUprGprApfCpfCpfCpfUpfUpfCpfCpfCprGprApfCprGpfCprApfCprGprGprApfCpfCprAprGpfUprGprApfUprGpfCpfCprAprApfCpfCpfCprApfCpfCpfCprGpfCpfCpfUprAprGprApfUprGprGprAprGpfUpfUprGprAprApfUpfUpfCpfUpfCpfCpfCpfUprApfUprAprGpfUprGprAprGpfUpfCprGpfUprApfUpfUprApfCp-3'

Molecular Weight: 34315.32

Extinction Coefficient: 1039800

Binding Conditions / Buffer

50 uM RNA containing 20 mM glucose.

Binding Temp:

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Ulrich et al. "In Vitro Selection of RNA Aptamers That Bind to Cell Adhesion Receptors of Trypanosoma cruzi and Inhibit Cell Invasion." The Journal of Biological Chemistry, 277 (2002): 20756-20762.

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