Aptagen

TROP2 (Tac B1) Aptamer Details

ID# 8162
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Structure
TROP2 (Tac B1) structure
Chemistry
DNA
Target
TROP2 FcHis / Human trophoblast antigen 2
Category
Protein
Affinity (Kd)
153 nM
Length
70
Aptazyme
No

Sequence (3-char table code)

G A C U/T
5'-dTpdCpdGpdCpdCpdTpdTpdGpdCpdCpdGpdGpdApdTpdCpdGpdCpdApdGpdApdTpdGpdCpdTpdGpdTpdTpdGpdTpdCpdApdCpdCpdTpdGpdCpdCpdTpdCpdGpdTpdCpdTpdCpdCpdCpdTpdCpdGpdTpfUpdGpdGpfUpdCpdCpdGpfUpdGpdApdGpdCpdCpfUpdGpdApdCpdApdCpdCp-3'
Molecular Weight:
Extinction Coefficient:

Binding Conditions / Buffer

Buffer, Annealing - 1 mM MgCl2 in PBS Buffer, Binding - 20 mM Tris-HCl buffer [pH 7.4], 10 mM NaCl, 1 mM MgCl2, and 0.05% Tween 20)
Binding Temp: 37°C

Refolding Protocol

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Uemachi, H.; Kasahara, Y.; Tanaka, K.; Okuda, T.; Yoneda, Y.; and S. Obika. 2021 . Hybrid-Type SELEX for the Selection of Artificial Nucleic Acid Aptamers Exhibiting Cell Internalization Activity. Pharmaceutics 2021, 13, 888. https://doi.org/10.3390/pharmaceutics13060888
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