TfRA4 Aptamer Details
ID# 8192
Structure
Chemistry
DNA
Target
TfR-positive cells
Category
Protein
Affinity (Kd)
487.3 ±108.8 nM nM
Length
14
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-dGpdCpdGpdTpdCpdGpdTpdApdCpdCpdApdCpdGpdCp-3'
Molecular Weight: 4338
Extinction Coefficient: 146
Binding Conditions / Buffer
Binding Temp: 37°C
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Macdonald, J., Houghton, P., Xiang, D., Duan, W., & Shigdar, S. (2016). Truncation and Mutation of a Transferrin Receptor Aptamer Enhances Binding Affinity. Nucleic Acid Therapeutics, 26(6), 348–354. doi:10.1089/nat.2015.0585
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