Terminal 8-oxodG DNA Lesion (R10-B35) Aptamer Details

ID# 7852

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Structure

Chemistry

RNA

Target

DNA Lesion 7,8-dihydro-8-hydroxy-2'-deoxyguanosine (8-oxodG)

Sequence (3-char table code)

G A C U/T

5'-rGprGprGprCprGprAprAprUprUprCprCprCprGprAprGprGprAprCprCprAprAprAprUprAprGprUprAprCprCprAprCprCprCprGprGprGprAprAprAprAprCprAprGprCprUprAprAprUprGprCprCprGprAprAprAprCprGprGprAprGprAprUprUprUprUprUprUprCprUprGprCprAprGprAprAprGprCprUp-3'

Molecular Weight: 25157.29

Extinction Coefficient: 782200

Binding Conditions / Buffer

Binding buffer: 20 mM NH4CH3CO2 (pH 6.0), 300 mM NaCl, and 5 mM MgCl2.

Binding Temp: RT°C

Refolding Protocol

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Rink, S. M. et al. "Creation of RNA molecules that recognize the oxidative lesion 7,8-dihydro-8-hydroxy-2*-deoxyguanosine (8-oxodG) in DNA." Proc. Natl. Acad. Sci., 95 (1998):11619-11624.

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