TEPP Aptamer Details

ID# 8175

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Structure

Chemistry

DNA

Target

Tfr (transferrin receptor) / EpCAM (epithelial cell adhesion molecule)

Sequence (3-char table code)

G A C U/T

5'-dGpdCpdGpdCpdGpdGpdTpdApdCpdCpdGpdCpdGpdCpdTpdApdApdCpdGpdGpdApdGpdGpdTpdTpdGpdCpdGpdTpdCpdCpdGpdTp-3'

Molecular Weight:

Extinction Coefficient:

Binding Conditions / Buffer

0.1 M sodium acetate (CH3COONa), 0.05 M sodium chloride (NaCl), and 5 mM MgCl2

Binding Temp: 37°C

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Macdonald, J., Denoyer, D., Henri, J., Jamieson, A., Burvenich, I. J. G., Pouliot, N., and S. Shigar. 2020. Bifunctional Aptamer–Doxorubicin Conjugate Crosses the Blood–Brain Barrier and Selectively Delivers Its Payload to EpCAM-Positive Tumor Cells. Nucleic Acid Therapeutics 30:2: 117-128. DOI: 10.1089/nat.2019.0807

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