TAR S3 Aptamer Details

ID# 9283

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Structure

Chemistry

RNA

Target

Intranuclear RNA-protein interactions involving HIV-1 Tat protein and TAR RNA

Sequence (3-char table code)

G A C U/T

5'-rCprAprCprGprAprCprGprCprAprAprGprGprGprAprCprCprAprCprAprGprGprAprGprGprCprCprCprAprGprGprCprUprGprCprUprUprGprCprCprCprCprGprGprAprAprCprCprAprGprCprAprCprGprAprCprAprCprCprGprCprAprGprAprGprGprCprAp-3'

Molecular Weight: 20589.3 g/mole

Extinction Coefficient: 635700

Binding Conditions / Buffer

Buffer: 50 mM Tris, 50 mM KCl, 0.01% Triton-X-100, pH = 7.4.

Binding Temp: 25 °C °C

Refolding Protocol

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Li, J., Yao, P., Tang, K., Zhao, X., Liu, X., Liu, Q., Wei, T., Xuan, H., Bian, S., Guo, Y., Yang, Z., Zhang, Z. Q., & Zhang, L. (2024). Functional Aptamers In Vitro Evolution for Intranuclear Blockage of RNA-Protein Interaction. Journal of the American Chemical Society, 146(35), 24654–24662. https://doi.org/10.1021/jacs.4c08824.

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