SP6 Aptamer Details
ID# 8169
Structure
Chemistry
DNA
Target
SARS-Co V-2 Spike (RBD independent mechanism to neutralize SARS-CoV-2)
Category
Protein
Affinity (Kd)
21 ± 4.6 nM
Length
86
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-dGpdGpdGpdApdGpdApdGpdGpdApdGpdGpdGpdApdGpdApdTpdApdGpdApdTpdApdTpdCpdApdApdCpdCpdCpdApdTpdGpdGpdTpdApdGpdGpdTpdApdTpdTpdGpdCpdTpdTpdGpdGpdTpdApdGpdGpdGpdApdTpdApdGpdTpdGpdGpdGpdCpdTpdTpdGpdApdTpdGpdTpdTpdTpdCpdGpdTpdGpdGpdApdTpdGpdCpdCpdApdCpdApdGpdGpdApdCp-3’
Molecular Weight:
Extinction Coefficient:
Binding Conditions / Buffer
PBS/3mM MgCl2/0.8 mg/mL BSA (PBS: 137 mM NaCl, 2.7 mM KCl, 10 nM NH4PO4, 1.76 mM KH2PO4 pH 7.4)
Binding Temp: 37°C
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Schmitz, A., Weber, A., Bayin, M., Breuers, S., Fieberg, V., Famulok, M., & Mayer, G. (2021). A SARS‐CoV‐2 Spike Binding DNA Aptamer that Inhibits Pseudovirus Infection by an RBD‐Independent Mechanism. Angewandte Chemie International Edition, 60(18), 10279-10285.
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