SL1111_20 Aptamer Details

ID# 8240

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Structure

Chemistry

DNA

Target

RBD of SARS-COV-2 Spike protein (monomer or trimer)

Sequence (3-char table code)

G A C U/T

5'-dGpdGpdGpdApdTpdApdCpdTpdApdTpdGpdCpdGpdTpdCpdCpdGpdApdCpdCpdGpdCpdTpdCpdGpdGpdApdCpdGp-3'

Molecular Weight:

Extinction Coefficient:

Binding Conditions / Buffer

37°C

Binding Temp: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Gelinas, A. D., Tan, T. K., Liu, S., Jaramillo, J. G., Chadwick, J., Harding, A. C., Zhang, C., Ream, B. E., Chase, C. N., Otis, M. R., Lee, T., Schneider, D. J., James, W. S., & Janjic, N. (2023). Broadly neutralizing aptamers to SARS-COV-2: A diverse panel of modified DNA antiviral agents. Molecular Therapy - Nucleic Acids, 31, 370–382. https://doi.org/10.1016/j.omtn.2023.01.008

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