SARS-CoV-2 RBD-4C Aptamer Details
ID# 8008
Structure
Chemistry
DNA
Target
SARS CoV-2
Category
Other
Affinity (Kd)
19.9 nM
Length
75
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-dApdTpdCpdCpdApdGpdApdGpdTpdGpdApdCpdGpdCpdApdGpdCpdApdTpdTpdTpdCpdApdTpdCpdGpdGpdGpdTpdCpdCpdApdApdApdApdGpdGpdGpdGpdCpdTpdGpdCpdTpdCpdGpdGpdGpdApdTpdTpdGpdCpdGpdGpdApdTpdApdTpdGpdGpdApdCpdApdCpdGpdTp-3'
Molecular Weight: 20788.5
Extinction Coefficient: 650500
Binding Conditions / Buffer
PBS containing 136.8 mM NaCl, 10.1 mM Na2HP04 ,2.7 mM KCl, 1.8 mM KH2PO4, 0.55mM MgCl2 pH=7.4
Binding Temp: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Discovery of Aptamers Targeting Receptor-Binding Domain of the SARS-CoV-2 Spike Glycoprotein (2020)
Yanling Song,*a Jia Song,b Xinyu Wei,a Mengjiao Huang,a Miao Sun,a Lin Zhu,a Bingqian Lin,a Haicong Shen,a Zhi Zhu,a Chaoyong Yang *a,b
*a. The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China
*b. Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China
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