RNV95 Aptamer Details
ID# 9529
Structure
Chemistry
DNA
Target
ABeta40
Category
Peptide
Affinity (Kd)
150-200 nM
Length
80
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-dApdCpdApdApdApdGpdCpdGpdApdCpdApdCpdApdCpdApdGpdGpdApdGpdCpdCpdTpdGpdGpdGpdGpdGpdGpdCpdGpdGpdApdCpdGpdApdTpdApdGpdGpdGpdGpdCpdCpdCpdCpdCpdCpdGpdGpdTpdApdGpdGpdApdTpdGpdGpdApdCpdGpdGpdGpdApdCpdApdGpdGpdApdCpdCpdApdCpdApdCpdCpdCpdApdGpdCpdGp-3'
Molecular Weight: 24878.1 g/mole
Extinction Coefficient: 786200
Binding Conditions / Buffer
10 mM Tris, 150 mM NaCl, 5 mM MgCl2, and 5 mM KCl
Binding Temp:
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Chakravarthy M, H Alshamaileh, H Huang, RK Tannenberg, S Chen, S Worrall, PR Dodd and RN Veedu. (2018). Development of DNA aptamers targeting low-molecular weight amyloid-b peptide aggregates: in vitro. Chem Commun 54:4593–4596. DOI https://doi.org/10.1039/C8CC02256A
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