RNase H1 (VI-2) Aptamer Details
ID# 7521
Structure
Chemistry
DNA
Target
RNase H1
Category
Protein
Affinity (Kd)
11 nM
Length
39
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-dCpdGpdGpdTpdCpdGpdCpdTpdCpdCpdGpdTpdGpdTpdGpdGpdCpdTpdTpdGpdGpdGpdTpdTpdGpdGpdGpdTpdGpdTpdGpdGpdCpdApdGpdTpdGpdApdCp-3'
Molecular Weight: 12149.88
Extinction Coefficient: 356700
Binding Conditions / Buffer
Buffer A (30 mM Trisƒ??HCl (pH 8.5), 40 mM ammonium sulfate, 20 mM magnesium chloride, and 0.01% 2-mercaptoethanol)
Binding Temp:
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Pileur, et al. "Selective inhibitory DNA aptamers of the human RNase H1." Nucleic Acids Research, 31 (2003): 5776-5788.
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