Receptor Tyrosine Kinase (RET) Mutant (D4) Aptamer Details

ID# 7500

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Structure

Chemistry

2'-F-RNA

Target

Receptor Tyrosine Kinase (RET) Mutant

Sequence (3-char table code)

G A C U/T

5'-rGpfCprGpfCprGprGprGprAprApfUprAprGpfUprApfUprGprGprAprAprGprGprApfUprApfCprGpfUprApfUprApfCpfCprGpfUprGpfCprAprApfUpfCpfCprAprGprGprGpfCprAprApfCprGp-3'

Molecular Weight: 16281.84

Extinction Coefficient: 511900

Binding Conditions / Buffer

Selection buffer: RPMI 1640

Binding Temp: 37°C

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Cerchia, Laura, et al. "Neutralizing Aptamers from Whole-Cell SELEX Inhibit the RET Receptor Tyrosine Kinase." PLoS Biology, 3 (2004): e123

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