R7-02 ssDNA aptamer scaffold for SARS-CoV-2 RBD (HOLD-selected) Aptamer Details
ID# 9703
Structure
Chemistry
DNA
Target
SARS-CoV-2 Spike RBD
Category
Protein
Affinity (Kd)
5.702 nM
Length
60
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-dGpdGpdApdApdGpdApdGpdApdTpdGpdGpdCpdGpdApdCpdApdCpdGpdCpdApdApdTpdCpdGpdTpdGpdGpdGpdTpdTpdGpdGpdGpdGpdApdTpdApdTpdApdApdTpdGpdGpdTpdApdApdGpdCpdTpdGpdApdTpdCpdCpdTpdGpdApdTpdGpdGp-3'
Molecular Weight: 18789.2 g/mole
Extinction Coefficient: 603800
Binding Conditions / Buffer
1X PBSMT [consisted of 1× PBS (pH 7.4), 2.5 mM MgCl2 and 0.02% Tween 20]
Binding Temp: 25°C
Refolding Protocol
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Lee, M., Kang, B., Lee, J., Lee, J., Jung, S. T., Son, C. Y., & Oh, S. S. (2022). De novo selected hACE2 mimics that integrate hotspot peptides with aptameric scaffolds for binding tolerance of SARS-CoV-2 variants. Science advances, 8(43), eabq6207. https://doi.org/10.1126/sciadv.abq6207
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