R24 Aptamer Details
ID# 8215
Structure
Chemistry
RNA
Target
Bovine PrP
Category
Protein
Affinity (Kd)
61 nM
Length
24
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-rGprGprAprGprGprAprGprGprAprGprGprAprGprGprAprGprGprAprGprGprAprGprGprAp-3'
Molecular Weight: 7711 g/mole
Extinction Coefficient: 269100
Binding Conditions / Buffer
20 mM Tris-HCl (pH 7.5) and 10 mM KCl
Binding Temp: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Mashima, T., Lee, JH., Kamatari, Y.O. et al. Development and structural determination of an anti-PrPC aptamer that blocks pathological conformational conversion of prion protein. Sci Rep 10, 4934 (2020).
Mollasalehi N., Francois-Moutal L., Porciani D., Burke D.H., & Khanna M. (2022). Aptamers Targeting Hallmark Proteins of Neurodegeneration. Nucleic Acid Therapeutics, 32(4). https://doi.org/10.1089/nat.2021.0091
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