R12-A-R12 (Bovine PrP) Aptamer Details

ID# 10147

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Structure

Chemistry

RNA

Target

Bovine Cell Prions

Sequence (3-char table code)

G A C U/T

5'-rGprGprAprGprGprAprGprGprAprGprGprAprAprGprGprAprGprGprAprGprGprAprGprGprAp-3'

Molecular Weight: 8024.2 g/mole

Extinction Coefficient: 281100

Binding Conditions / Buffer

10 mM K-phosphate (pH 6.2) and 100 mM KCl

Binding Temp:

Refolding Protocol

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Mashima, T., Lee, JH., Kamatari, Y.O. et al. Development and structural determination of an anti-PrPC aptamer that blocks pathological conformational conversion of prion protein. Sci Rep 10, 4934 (2020). https://doi.org/10.1038/s41598-020-61966-4

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