Protein Tyrosine Phosphatase (N71yc16) Aptamer Details

ID# 7541

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Structure

Chemistry

RNA

Target

Protein tyrosine phosphatase (PTPase)

Sequence (3-char table code)

G A C U/T

5'-rGprGprGprAprGprAprUprAprCprCprAprGprCprUprUprAprUprUprCprAprAprUprUprCprUprGprGprCprAprAprUprGprGprGprCprUprAprUprCprCprCprAprAprGprUprGprCprUprAprGprGprCprUprUprCprAprGprGprGprAprGprCprGprAprGprGprAprCprCprAprGprAprCprGprAprCprGprUprAprCprCprUprAprAprCprCprCprUprAprAprGprGprUprGprAprGprAprUprAprGprUprAprAprGprUprGprCprAprAprUprCprUp-3'

Molecular Weight: 36151.85

Extinction Coefficient: 1126100

Binding Conditions / Buffer

Selection Buffer (20 mM Tris (pH 7.6), 150 mM NaCl, 5 mM MgCl2, 1 mM dithiothreitol; 100 µl final volume)

Binding Temp:

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Bell, S., et al. "RNA Molecules That Bind to and Inhibit the Active Site of a Tyrosine Phosphatase." The Journal of Biological Chemistry, 273(1998):14309-14314.

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