Plasminogen Activator Inhibitor-1 (paionap-5) Aptamer Details

ID# 7829

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Structure

Chemistry

2'-F-RNA

Target

Plasminogen Activator Inhibitor-1

Sequence (3-char table code)

G A C U/T

5'-rGprGprGprGpfCpfCprApfCpfCprAprApfCprGprApfCprApfUpfUprGprAprApfCpfCprApfCprGpfUprAprGprGpfCpfUpfCprGpfUpfUpfUpfCpfUprGprAprGpfCpfCprGprApfUpfCpfUpfCprGprApfUprGpfUpfUprGprApfUprApfUprAprAprApfUprAprGpfUprGpfCpfCpfCprApfUprGprGprApfUpfCp-3'

Molecular Weight: 25425.08

Extinction Coefficient: 779600

Binding Conditions / Buffer

HBS buffer (pH 7.4), 2mM MgCl2, 0.05% Tween 20.

Binding Temp:

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Madsen, J.B., et al. "RNA Aptamers as Conformational Probes and Regulatory Agents for Plasminogen Activator Inhibitor-1." Biochemistry, 49, (2010), 4103-4115.

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