PL1 Aptamer Details

ID# 8058

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Structure

Chemistry

DNA

Target

PD-L1

Sequence (3-char table code)

G A C U/T

5'-dApdTpdApdCpdCpdApdGpdCpdTpdTpdApdTpdTpdCpdApdApdTpdTpdGpdTpdApdGpdApdGpdTpdApdTpdApdApdApdApdApdGpdApdGpdTpdGpdApdTpdGpdApdTpdCpdTpdTpdTpdTpdGpdTpdApdGpdGpdTpdTpdTpdTpdTpdTpdApdGpdApdTpdApdGpdTpdApdApdGpdTpdGpdCpdApdApdTpdCpdTp-3'

Molecular Weight: 23552.4

Extinction Coefficient: 768500

Binding Conditions / Buffer

0.1 mg/mL yeast tRNA, 1 mg/mL BSA, 4.5 g/L glucose, and 5 mM MgCl2 in Dulbecco’s PBS without calcium and magnesium

Binding Temp: 4°C

Refolding Protocol

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Gao T, Mao Z, Li W, Pei R. "Anti-PD-L1 DNA aptamer antagonizes the interaction of PD1/PD-L1 with antitumor effect." Journal of Materials Chemistry B, 2021, 9, 746-756. DOI: 10.1039/D0TB01668C

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