Periostin Aptamer (PNDA-3) Aptamer Details

ID# 7890

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Structure

Chemistry

RNA

Target

Periostin

Sequence (3-char table code)

G A C U/T

5'-dApdCpdGpdApdGpdTpdTpdGpdTpdCpdGpdCpdApdTpdGpdTpdGpdCpdGpdGpdTpdTpdCpdApdGpdTpdCpdTpdGpdGpdTpdCpdCpdTpdTpdCpdApdGpdCpdApdCpdCpdGpdTpdApdCpdApdApdCpdApdAp-3'

Molecular Weight: 15666.2

Extinction Coefficient: 483400

Binding Conditions / Buffer

40 mM/1 HEPES, 102 mM/1 NaCl, 5 mM/1mol/1g Cl2,5 mM KCl

Binding Temp: 37°C

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Lee, Y., Kim, I., Park, S., Kim, Y., Wu, S., Lee, J., Noh, D., Kim, K., Ryu, S. and Suh, P. "Periostin-binding DNA aptamer inhibits breast cancer growth and metastasis." The American Society of Gene & Cell Therapy 21.5 (2013): 1004-13.

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