Osteopontin (OPN-R3) Aptamer Details
ID# 7736
Structure
Chemistry
2'-F-RNA
Target
Human Osteopontin
Category
Protein
Affinity (Kd)
18 nM
Length
40
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-fCprGprGpfCpfCprApfCprAprGprAp rApfUprGprAprAprAprAprApfCpfCp fUpfCprApfUpfCprGprApfUprGpfUp fUprGpfCprApfUprAprGpfUpfUprGp -3'
Molecular Weight: 12862.72
Extinction Coefficient: 402900
Binding Conditions / Buffer
Binding Buffer: PBS (137 nM NaCl, 27 nM KCl, 100 nM Na2HPO4, 2 nM K2HPO4, pH 7.4)
Binding Temp: 37°C
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Z Mi et al. RNA aptamer blockade of osteopontin inhibits growth and metastasis of MDA-MB231 breast cancer cells. Molecular Therapy 17(2009): 153-161
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