Neurotrophin receptor, TrkB (C4-3) Aptamer Details
ID# 7691
Structure
Chemistry
2'-F-RNA
Target
Neurotrophin receptor, TrkB
Category
Protein
Affinity (Kd)
2.1 nM
Length
51
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-rGprGprGprAprGprGprApfCprGprApfUprGpfCprGprGp fUpfCprGpfUprApfUpfUprApfUpfCpfCprGpfCpfUprGpfCprApfCprGpfCp fCprAprGprApfCprGprApfCpfUpfCprGpfCpfCpfCprGprAp-3'
Molecular Weight: 16478.87
Extinction Coefficient: 490000
Binding Conditions / Buffer
DPBS Running Buffer: 0.901 mM CaCl2, 0.493 mM MgCl2, 2.67 mM KCl, 1.47 mM KH2PO4 , 137.93 mM NaCl and 8.06 mM Na2HPO4.
Binding Temp: 37°C
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Huang, Y. (2012). RNA aptamer-based functional ligands of the neurotrophin receptor, TrkB. J. Pharmacol. Exp. Ther. 82(2012):623-635.
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