Mycobacterium tuberculosis (strain H37Rv) (aptamer NK2) Aptamer Details

ID# 7788

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Structure

Chemistry

DNA

Target

Virulent mycobacterium tuberculosis (H37Rv)

Sequence (3-char table code)

G A C U/T

5'-dGpdCpdGpdGpdGpdApdTpdCpdCpdTpdApdTpdGpdApdCpdGpdCpdApdTpdTpdGpdApdCpdCpdCpdApdCpdApdApdCpdApdCpdApdCpdTpdApdCpdTpdGpdTpdCpdGpdCpdTpdCpdGpdGpdTpdTpdCpdGpdApdApdCpdTpdTpdCpdGpdTpdGpdCpdGpdApdCpdTpdGpdTpdTpdCpdCpdCpdTpdApdTpdApdGpdTpdGpdApdGpdTpdCpdGpdTpdApdTpdTpdApdGpdApdApdTpdTpdCpdCpdGpdCp-3'

Molecular Weight: 29764.31

Extinction Coefficient: 909900

Binding Conditions / Buffer

Binding buffer: 25 mM Tris-HCl, 50 mM KCl, 200 mM NaCl, 0.2 mM EDTA, 5.0% (v/v) glycerol, and 0.5 mM DTT.

Binding Temp: 37°C

Refolding Protocol

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Fan et al. "Aptamer from whole-bacterium SELEX as new theraputic reagent against virulent Mycobacterium Tuberculosis." Biochem. Bioph. Res. Co., 357, (2007): 743-748. Fan et al. "Aptamer Inhibits Mycobacterium Tuberculosis (H37Rv) Invasion of Macrophage." Mol. Biol. Rep., 39, (2012): 2157-2162.

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