MUC1 Tumor Marker (MUC1-5TR-1) Aptamer Details
ID# 7810
Structure
Chemistry
DNA
Target
MUC1 recombinant protein with five repeats of the variable tandem repeat region
Category
Protein
Affinity (Kd)
47.3 nM
Length
72
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-dGpdGpdGpdApdGpdApdCpdApdApdGpdApdApdTpdApdApdApdCpdGpdCpdTpdCpdApdAp dGpdApdApdGpdTpdGpdApdApdApdApdTpdGpdApdCpdApdGpdApdApdCpdApdCpdApdApdCpdAp dTpdTpdCpdGpdApdCpdApdGpdGpdApdGpdGpdCpdTpdCpdApdCpdApdApdCpdApdGpdGpdCp -3'
Molecular Weight: 22353.64
Extinction Coefficient: 748000
Binding Conditions / Buffer
Running Buffer for SPR/Binding Buffer: 100 mM NaCl, 5 mM MgCl2, pH 7.4.
Binding Temp: 37°C
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
C Ferreira et al. DNA aptamers against the MUC1 tumour marker: design of aptamer-antibody sandwich ELISA for the early diagnosis of epithelial tumors. Anal. Bioanal. Chem. 390(2008):1039-1050.
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