MS3 Aptamer Details

ID# 8203

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Structure

Chemistry

DNA

Target

Huntingtin

Sequence (3-char table code)

G A C U/T

5'-dGpdGpdGpdApdGpdGpdGpdApdGpdGpdGpdApdGpdGpdGpdApdGpdGpdGpdApdGpdGpdGpdApdGpdGpdGpdApdGpdGpdGpdApdGpdGpdGpdAp-3'

Molecular Weight: 11724.57

Extinction Coefficient:

Binding Conditions / Buffer

Sodium Phosphate Buffer: 10 mM NaH2PO4/Na2HPO4, 90 mM NaCl, pH 7.0 PBS: 137 mM NaCl, 2.7 mM KCl, 10 mM NaH2PO4/Na2HPO4, 1.8 mM KH2PO4/K2HPO4, pH = 7.3

Binding Temp:

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Riccardi C, D’Aria F, Digilio FA, Carillo MR, Amato J, Fasano D, De Rosa L, Paladino S, Melone MAB, Montesarchio D, Giancola C. Fighting the Huntington’s Disease with a G-Quadruplex-Forming Aptamer Specifically Binding to Mutant Huntingtin Protein: Biophysical Characterization, In Vitro and In Vivo Studies. International Journal of Molecular Sciences. 2022; 23(9):4804. https://doi.org/10.3390/ijms23094804

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