L15.20.1 HIV Capsid Protein Hexamer Lattice Aptamer Aptamer Details

ID# 8970

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Structure

Chemistry

RNA

Target

Indazole-3-carboxamidesynthetic cannabinoids

Sequence (3-char table code)

G A C U/T

5'-rGprGprAprAprGprAprAprGprAprGprAprAprUprCprAprUprAprCprAprCprAprAprGprAprGprGprGprUprCprGprCprAprUprCprGprGprUprCprUprCprUprAprUprGprGprAprUprAprAprAprUprCprUprGprCprCprUprUprAprUprUprGprGprAprGprGprAprUprGprGprGprAprAprAprUprGprUprGprGprAprGprGprGprCprAprUprAprAprGprGprUprAprGprGprUprAprAprGprUprCprCprAprUprAp

Molecular Weight: 33837.4 g/mole

Extinction Coefficient: 1090300

Binding Conditions / Buffer

50 mM Tris-HCl [pH 7.5], 100 mM KCl, 50 mM NaCl, 1 mM MgCl2 at 37°C

Binding Temp: 37°C

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

A Branched SELEX Approach Identifies RNA Aptamers That Bind Distinct HIV-1 Capsid Structural Components Paige R. Gruenke, Miles D. Mayer, Rachna Aneja, William J. Schulze, Zhenwei Song, Donald H. Burke, Xiao Heng, and Margaret J. Lange ACS Infectious Diseases 2024 10 (8), 2637-2655 DOI: 10.1021/acsinfecdis.3c00708

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