KM41 Aptamer Details
ID# 8219
Structure
Chemistry
RNA
Target
A-beta40
Category
Protein
Affinity (Kd)
N/A nM
Length
37
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-rUprAprAprUprAprCprGprAprCprUprCprAprCprUprAprUprAprGprGprGprAprAprUprUprCprGprAprGprCprUprCprGprGprUprAprCprCp-3'
Molecular Weight: 11900
Extinction Coefficient: 373800
Binding Conditions / Buffer
140 mM NaCL, 2.7 mM KCl, 10 mM Na2HPO4-, 2mM KH2PO4, pH 7.4
Binding Temp: 23°C
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Rahimi F, Murakami K, Summers JL, Chen C-HB, Bitan G (2009) RNA Aptamers Generated against Oligomeric Ab40 Recognize Common Amyloid Aptatopes with Low Specificity but High Sensitivity. PLoS ONE 4(11): e7694.
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