IR-A48 Aptamer Details
ID# 7957
Structure
Chemistry
DNA
Target
Insulin Receptor
Category
Protein
Affinity (Kd)
3.5 nM
Length
33
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-dCpdGpdCpdCpdTpdGpdGpdNpdGpdNpdNpdApdApdGpdApdCpdApdApdCpdCpdNpdCpdNpdApdGpdGpdNpdCpdApdGpdGpdCpdGp-3'
Molecular Weight: 10129.43
Extinction Coefficient: 313200
Binding Conditions / Buffer
Krebs-Ringer HEPES Buffer. Tested in vivo.
Binding Temp: 37°C
Refolding Protocol
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Yunn N, Koh A, Han S, Lim JH, Park S, et al. (2015) Agonistic Aptamer to the Insulin Receptor Leads to Biased Signaling and Functional Selectivity Through Allosteric Modulation. Nucleic Acids Research 1. doi:10.1093/narlgkv767
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