Interleukin 8 (8A-35) Aptamer Details
ID# 7970
Structure
Chemistry
2'-F-RNA
Target
Interleukin-8 (CXCL-8)
Category
Protein
Affinity (Kd)
1.72 pM
Length
35
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-rGprGprGprGprGpfCpfUpfUprApfUpfCprApfUpfUpfCpfCprApfUpfUpfUprAprGpfUprGpfUpfUprApfUprGprApfUprAprApfCpfCp-3'
Molecular Weight: 11182.56
Extinction Coefficient: 353800
Binding Conditions / Buffer
30 mM Tris-HCl (pH 7.5), 150 mM NaCl, 1.5 mM MgCl2, 2mM DTT, and 1% BSA
Binding Temp: 23°C
Refolding Protocol
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Sung HJ, Choi S, Lee JW, Ok CY, Bae YS, Kim YH, Lee W, Heo K, Kim IH. Inhibition of human neutrophil activity by an RNA aptamer bound to interleukin-8. Biomaterials. 2014 Jan;35(1):578-89. doi: 10.1016/j.biomaterials.2013.09.107. Epub 2013 Oct 13.
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