Interleukin 17A/F (IL-17A/F) (AptAF42dope1) Aptamer Details

ID# 7706

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Structure

Chemistry

2'-F-RNA

Target

Interleukin-17A/F

Sequence (3-char table code)

G A C U/T

5'-rGprGprGp fCpfUprAp rGpfCpfUp rGprApfUp fCprGpfUp rApfCpfCp rAprGpfUp rAprGpfCp rGpfUprGp rGpfCpfCp fUprGprGp rGprGprGp rGpfCpfCp fUprAprGp fUpfCprGp fUprGpfCp rGprApfUp rApfCpfUp rAprApfCp rAprGpfCp fUprAprAp fCprApfCp fCpfCp-3'

Molecular Weight: 21984.1

Extinction Coefficient: 657400

Binding Conditions / Buffer

Binding buffer-145mM sodium chloride, 5.4 mM potassium chloride, 0.8 mM magnesium chloride, 1.8 mM calcium chloride, 20 mM Tris-HCl (pH 7.6) supplemented with 0.05% Tween20

Binding Temp:

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Adachi, H et al. (2011). Antagonistic rna aptamer specific to a heterodimeric form of human interleukin-17a/f. Biochimie, 93(2011), 1081-1088. doi: 10.1016/j.biochi.2011.04.003

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