Interleukin-17A/F (IL-17A/F) (APTAF42) Aptamer Details
ID# 7525
Structure
Chemistry
2'-F-RNA
Target
Human Interleukin-17A/F
Category
Protein
Affinity (Kd)
72.2 nM
Length
69
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-rGprGprGpfCpfUprAprGpfCpfUprGprApfUpfCprGpfUprApfCpfCpfCprAprGpfUprAprGpfCprGpfUprGprGpfCprApfUprGprGprGprGpfUprGpfCpfCpfUprAprGpfUpfCprGprGprGpfCprGprApfUprApfCpfUprAprApfCprAprGpfCpfUprAprApfCprApfCpfCpfCp-3'
Molecular Weight: 22313.31
Extinction Coefficient: 670800
Binding Conditions / Buffer
Binding Buffer (145 mM sodium chloride, 5.4 mM potassium chloride, 0.8 mM magnesium chloride, 1.8 mM calcium chloride, 20 mM Trisƒ??HCl (pH 7.6) supplemented with 0.05% Tween20
Binding Temp:
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Adachi, H., et al. "Antagonistic RNA aptamer specific to a heterodimeric form of human interleukin-17A/F." Biochemie, 93 (2011): 1081-1088.
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