HuNoV-GII Aptamer Aptamer Details

ID# 9298

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Structure

Chemistry

DNA

Target

Human Norovirus GII.4 & GII.17 Virus-Like Particles (VLPs)

Sequence (3-char table code)

G A C U/T

5'-dCpdApdGpdGpdGpdGpdGpdApdCpdGpdCpdApdCpdCpdCpdApdApdGpdGpdApdTpdCpdApdCpdGpdCpdApdGpdCpdApdCpdGpdCpdGpdGpdGpdGpdTpdCpdApdTpdGpdGp-3'

Molecular Weight: ~18-25 kDa

Extinction Coefficient:

Binding Conditions / Buffer

Binding assays were conducted at 37°C using PBST buffer supplemented with 5 mM MgCl₂. Aptamer concentrations ranged from 0.01 to 2.0 µM, and target VLP concentrations ranged from 1.5 to 10 µg/mL.

Binding Temp: 37°C

Refolding Protocol

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Cheng, C., Sun, M., Li, J., Xue, Y., Cai, X., Liu, J., Wang, X., Xu, S., Xie, Y., & Zhang, J. (2025). Nucleic acid aptamers for human norovirus GII.4 and GII.17 virus-like particles (VLPs) exhibit specific binding and inhibit VLPs from entering cells. International Journal of Nanomedicine, 20, 1789–1805. https://doi.org/10.2147/IJN.S495399

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