Human Nonpancreatic Secretory Phospholipase A2 (Aptamer 15) Aptamer Details
ID# 7536
Structure
Chemistry
DNA
Target
Human Nonpancreatic Secretory Phospholipase A2 (hnps-PLA2)
Category
Small Organic
Affinity (Kd)
1.7 nM
Length
51
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-rGprGprGprAprAprAprAprGprAprGprApnCprGprGpnCpnCprGprGpnCprGpnCpnCprApnUprAprGpnCpnCprGprAprGprApnUpnCpnCprGprAprGprGpnUprGpnUpnUprGpnCpnCprGprAprGprAprAp-3'
Molecular Weight: 26999.39
Extinction Coefficient: 513200
Binding Conditions / Buffer
Tris-buffered saline (25 mM Tris, pH 7.4, 150 mM NaCl) Tris potassium calcium buffer (25 mM Tris, 2.5 mM CaCl2, 100 mM KCl)
Binding Temp:
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Bridonneau, P., et al. "High-Affinity Aptamers Selectively Inhibit Human Nonpancreatic Secretory Phospholipase A2 (hnps-PLA2)." Journal of Medicinal Chemistry, 41(1998): 778-786.
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