Human Matrix Metalloprotease 9 (hMMP-9) (F3) Aptamer Details

ID# 7742

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Structure

Chemistry

2'-F-RNA

Target

Human matrix metalloprotease 9 (hMMP-9)

Sequence (3-char table code)

G A C U/T

5'-rGprGpfUp fUprApfCp fCprAprGp fCpfCpfUp fUpfCprAp fCpfUprGp fCpfUpfCp fCpfCprGp rGprApfCp rGpfCprGp fUpfCpfUp rGpfUprAp fUpfCpfCp rGpfCpfUp rApfCpfCp fCprGpfCp fCprGpfCp rApfCpfCp rApfCprGp rGpfUpfCp rGprGpfUp fCprApfCp rApfCp-3'

Molecular Weight: 21667.8

Extinction Coefficient: 615600

Binding Conditions / Buffer

SP buffer: 50 mM Tris HCl, pH 7.4, 50 mM NaCl, 100 mM KCl, 5 mM CaCl2, 1 mM Magnesium Acetate.

Binding Temp: 23°C

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

S Gomes et al. A 99mTc-MAG3-aptamer for imaging human tumours associated with high level of matrix metalloproteinase-9. Bioconjugate Chem. (2012). Accepted for print. DOI: 10.1021/bc300146c.

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