HMGB1 L30 Aptamer Details
ID# 8976
Structure
Chemistry
DNA
Target
HMGB1
Category
Protein
Affinity (Kd)
214 ± 26 nM
Length
26
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
dTpdTpdApdGpdGpdGpdTpdApdTpdGpdGpdGpdTpdTpdTpdGpdGpdGpdApdTpdApdGpdGpdGpdTpdTp
Molecular Weight: 8183.3 g/mole
Extinction Coefficient: 259800
Binding Conditions / Buffer
23°C
Binding Temp: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Ettore Napolitano, Andrea Criscuolo, Claudia Riccardi, Chiara Platella, Rosa Gaglione, Angela Arciello, Domenica Musumeci, Daniela Montesarchio,
When annealing is detrimental: The case of HMGB1-targeting G-quadruplex aptamers,
International Journal of Biological Macromolecules,
Volume 283, Part 1, 2024, 137148,
ISSN 0141-8130,
https://doi.org/10.1016/j.ijbiomac.2024.137148.
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