HIV co-receptor CCR5 (BY6M4) Aptamer Details

ID# 7826

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Structure

Chemistry

Peptide

Target

CCR5

Sequence (3-char table code)

G A C U/T

5'-MetAlaTyrProTyrAspValProAspTyrAlaAspLeuProAsnLeuTrpPheIleIleIlePheLeuArgLeuValValLeuPheLeuLeuPheValIleValLeuIleArgAlaSerValLeuTyrTrp-3'

Molecular Weight: 6018.13

Extinction Coefficient:

Binding Conditions / Buffer

RPMI-10 medium

Binding Temp: 37°C

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Scheideman EH, DiMaio D, et al. (2012) Transmembrane protein aptamers that inhibit CCR5 expression and HIV coreceptor function. J. Virol. 86: 10281-10292.

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