HIV-1 R5 Glycoprotein gp120 (B4) Aptamer Details

ID# 7530

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Structure

Chemistry

2'-F-RNA

Target

HIV-1 R5 SU Glycoprotein

Sequence (3-char table code)

G A C U/T

5'-rAprApfUpfUprAprApfCpfCpfCpfUpfCprApfCpfUprAprAprAprGprGprGprAprApfCpfUprGpfUpfUprGpfUprGprAprGpfUpfCpfUpfCprApfUprGpfUpfCprGprAprAprGprAprGpfCprGprGpfUpfUprAprAprGprGprGprAprGprApfUpfUpfUprAprGprGpfCprAprGpfCprAprGpfCpfUpfUprGprGprApfCprAprGpfUprGpfUprApfUpfCprGprGpfCpfUprGprAprGpfUpfUprGprAprGpfCprGpfUpfCpfUprAprGpfUpfCpfUpfUprGpfUpfCpfUp-3'

Molecular Weight: 36897.78

Extinction Coefficient: 1148700

Binding Conditions / Buffer

HBS Buffer (10 mM HEPES (pH 7.4), 150 mM NaCl, 1 mM CaCl2, 1 mM MgCl2, 2.7 mM KCl)

Binding Temp:

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Khati, M., et al. "Neutralization of Infectivity of Diverse R5 Clinical Isolates of Human Immunodeficiency Virus Type 1 by gp120-Binding 2'F-RNA Aptamers." Journal of Virology, 77(2003): 12692-12698.

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