Heteroaryl dihydropyrimidine (Aptamer 21) Aptamer Details
ID# 7596
Structure
Chemistry
RNA
Target
Heteroaryldihydropyrimidine (HAP)
Category
Small Organic
Affinity (Kd)
50 nM
Length
79
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-rGprGprGprUprAprGprGprCprCprAprGprGprCprAprGprCprCprAprAprCprUprAprGprCprGprAprGprAprGprCprUprUprAprAprAprUprCprUprCprUprGprAprGprCprCprCprGprAprGprAprGprGprGprUprUprCprAprGprUprGprCprUprGprCprUprUprAprUprGprUprGprGprAprCprGprGprCprUprUp-3'
Molecular Weight: 25553.41
Extinction Coefficient: 774800
Binding Conditions / Buffer
Selection buffer: 150 mM NaCl, 5 mM MgCl2, and 50 mM HEPES (pH 7.4)
Binding Temp: 20°C
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Lau et al. "Evolution and Protein Packaging of Small-Molecule RNA Aptamers." ACS NANO, 5(2011): 7722-7729.
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