HER3 (A30) Aptamer Details
ID# 7478
Structure
Chemistry
RNA
Target
HER3
Category
Protein
Affinity (Kd)
45 nM
Length
79
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-rGprAprAprUprUprCprCprGprCprGprUprGprUprGprCprCprAprGprCprGprAprAprAprGprUprUprGprCprGprUprAprUprGprGprGprUprCprAprCprAprUprCprGprCprAprGprGprCprAprCprAprUprGprUprCprAprUprCprUprGprGprGprCprGprGprUprCprCprGprUprUprCprGprGprGprAprUprCprCp-3'
Molecular Weight: 25442.28
Extinction Coefficient: 761100
Binding Conditions / Buffer
Binding buffer: 10 mM HEPES (pH 7.4), 100 mM NaCl, and 2.5 mM MgCl2
Binding Temp: 37°C
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Chi-Hong et al. "Inhibition of heregulin signaling by an aptamer that preferentially binds to the oligomeric form of human epidermal growth factor receptor-3." Proceedings of the National Academy of Sciences of the United States of America 100,(2003):9226-9231.
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