Heparanase (3M NaSCN) Aptamer Details
ID# 7789
Structure
Chemistry
DNA
Target
Heparanase (HPSE1)
Category
Protein
Affinity (Kd)
13 nM
Length
72
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'- dGpdGpdGpdApdGpdApdCpdApdApdGp dApdApdTpdApdApdApdCpdGpdCpdTp dCpdApdApdTpdTpdTpdApdApdCpdGp dTpdApdTpdTpdTpdApdTpdTpdCpdAp dApdGpdCpdTpdCpdGpdTpdApdTpdTp dCpdGpdApdCpdApdGpdGpdApdGpdGp dCpdTpdCpdApdCpdApdApdCpdApdGp dGpdCp-3'
Molecular Weight: 22240.55
Extinction Coefficient: 719300
Binding Conditions / Buffer
Salt Solution: 100 mM NaCl, 20 mM KCl, 5 mM MgCl2
Binding Temp: RT°C
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Simmons, SC, et al. Development of novel single-stranded nucleic acid aptamers against the pro-angiogenic and metastatic enzyme heparanase (HPSE1). PLoS One (2012) 7:e37938.
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