HD3S/53 Aptamer Details
ID# 9551
Structure
Chemistry
DNA
Target
Htt
Category
Small Organic
Affinity (Kd)
77.2°C
Length
53
Aptazyme
No
Sequence (3-char table code)
G
A
C
U/T
5'-dGpdCpdTpdGpdTpdTpdGpdCpdTpdGpdCpdTpdGpdTpdTpdGpdTpdTpdGpdCpdTpdGpdTpdTpdGpdCpdApdGpdCpdTpdGpdTpdTpdGpdGpdApdApdGpdGpdApdCpdTpdTpdGpdApdGpdGpdGpdApdCpdTpdCpdGp-3'
Molecular Weight: 16479.6 g/mole
Extinction Coefficient: 486600
Binding Conditions / Buffer
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Binding Temp:
Refolding Protocol
If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Reference
Parekh-Olmedo, H., Wang, J., Gusella, J.F. et al. Modified single-stranded oligonucleotides inhibit aggregate formation and toxicity induced by expanded polyglutamine. J Mol Neurosci 24, 257–267 (2004). https://doi.org/10.1385/JMN:24:2:257
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