HA-LNA-1 for Influenza Virus Surface Protein HA Aptamer Details

ID# 9936

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Structure

Chemistry

L-DNA

Target

influenza virus surface protein HA

Sequence (3-char table code)

G A C U/T

5'-LdALdCLdGLdGLdALdALdALdCLdGLdALdTLdGLdALdALdTLdTLdGLdCLdGLdGLdGLdALdALdALdALdGLdCLdALdALdALdGLdCLdCLdALdALdALdALdGLdGLdC-3'

Molecular Weight: 12463.2 g/mole

Extinction Coefficient: 417500

Binding Conditions / Buffer

75.7°C

Binding Temp: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Refolding Protocol

If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference

Lock, Protect, and Bind: In Vitro Selection of LNA-modified Aptamers Using a Mutant T7 RNA Polymerase Kevin Neis, Laia Civit, Kathrine Pedersen, Michael Schachtner, Jesper Wengel, Ralf Wagner, Steffen Thiel, Jørgen Kjems, Julián Valero bioRxiv 2025.04.09.647959; doi: https://doi.org/10.1101/2025.04.09.647959

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